CNS Disease
Animal Model
Alzheimer's Disease (AD)
Familial AD in mice
A model of cholinergic neuron damage
Parkinson's Disease
Rat 6-OHDA induced model
Mouse and primate MPTP-induced models
Depression/Anxiety
Forced swimming, tail suspension, open field, elevated cross maze
Anxiety-like symptoms induced by M-CPP
Chronic moderate unpredictable stress (CUMS) model
Cerebral ischemia
Permanent occlusion/ischemia reperfusion of the middle cerebral artery in primates and rodents
Mechanical/thrombotic obstruction
Pain
Screening of central analgesic drugs (Hot plate, Tail Flick)
Inflammatory pain (carrageenan, formalin induced, acetic acid twisting)
Postoperative pain (Brennan method)
Chronic neuralgia (SNL), diabetic neuralgia (T1DM, T2DM)
Osteoarthritis (MIA induction)
Drug dependence
Self-administration, drug discrimination, conditioned location preference
Natural withdrawal, urge withdrawal
Nerve virulence